NAD+ therapy is gaining attention for its ability to boost energy, support brain health, and promote healthy aging.
But like any wellness treatment, it’s important to know about possible NAD+ side effects before you get started.
At Awaken IV in Scottsdale, we make sure your treatment is personalized, comfortable, and as safe as possible, so you can focus on feeling your best.
What Is NAD+ and Why It Matters for Your Health
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that’s found in every cell of your body.
It helps turn food into energy, supports healthy brain function, and assists with repairing DNA.
Studies show that your NAD+ levels naturally decline with age, which can lead to fatigue, slower metabolism, and other signs of aging.
Many people choose NAD+ IV therapy to replenish those levels and feel more energized.
At Awaken IV, we offer NAD+ treatments that are carefully monitored and customized to match your needs and health goals.
Common NAD+ Side Effects
Most people tolerate NAD+ well, but some mild and temporary side effects can happen, especially during your first few treatments.
- Nausea or stomach discomfort, often related to infusion speed or taking NAD+ without food
- Headaches or lightheadedness, sometimes from shifts in energy metabolism
- Flushing or a warm feeling, usually linked to IV delivery
- Muscle cramps or mild weakness, possibly tied to changes in electrolytes
- Fatigue, which can occur for a short time after therapy
What are Rare or Serious NAD+ Side Effects
Serious NAD + side effects are rare, but it’s good to be aware of them:
- Allergic reactions such as rash, itching, or trouble breathing
- Temporary changes in liver enzymes, particularly at higher doses
- Low platelet counts, which have been seen in some research
- Concerns about tumor growth from animal studies, though there’s no confirmed evidence in humans
Side Effects by Delivery Method
The type of NAD+ treatment you choose can affect your risk of side effects.
- Oral NAD+ supplements can cause mild digestive upset, nervousness, or headaches.
- NAD+ IV infusions may lead to flushing, nausea, dizziness, or headaches—especially if the infusion is too fast. Slowing the drip rate can help.
- NAD+ injections can cause minor soreness at the injection site, occasional flushing, or dizziness.
- Sublingual or nasal NAD+ may cause mild throat or nasal irritation, though research is limited.
Factors That Influence Your Risk of Side Effects
Your experience with NAD+ therapy can depend on several factors:
- How much NAD+ you receive and how often
- The speed of the infusion or injection
- Your overall health, especially liver, kidney, or heart function
- Any supplements or medications you’re taking
- Pregnancy or breastfeeding, where safety data is limited
How to Reduce NAD+ Side Effects
With the right approach, NAD+ therapy can be more comfortable and easier on your body.
- Choose a provider who customizes your dose and monitors your treatment, like Awaken IV
- Start with a lower dose or slower infusion rate
- Drink water before and after therapy to stay hydrated
- Eat a light meal before your session to help prevent nausea
- Space your sessions so your body has time to adjust
Who Should Avoid or Use NAD+ with Caution
NAD+ therapy may not be right for everyone.
It should be avoided or used carefully by people who are pregnant or breastfeeding, have serious liver or kidney issues, have active cancer or a history of certain tumors, or are taking medications that could interact with the treatment.
Why Choose Awaken IV for NAD+ Therapy
At Awaken IV, we take the time to understand your goals and design a treatment plan that works for you.
Your infusion is given under medical supervision, and we adjust the speed and dosage to help you get the benefits of NAD+ while minimizing side effects.
We use high-quality NAD+ in a relaxing, spa-like environment so you can feel confident about your treatment.
The Bottom Line on NAD+ Side Effects
Most NAD+ side effects are mild and short-lived, especially when therapy is done under the care of an experienced provider.
With personalized dosing, careful monitoring, and a comfortable setting, Awaken IV makes it possible to enjoy the potential benefits of NAD+ while reducing unwanted effects.
FAQs: NAD+ Side Effects
Who shouldn’t take NAD+?
NAD+ therapy isn’t recommended for people who are pregnant or breastfeeding, have serious liver or kidney disease, certain cancers, or take medications that may interact with it. Always consult a healthcare provider before starting.
What happens when you take NAD+ every day?
Daily NAD+ use may help maintain higher cellular energy levels, but frequent dosing can increase the risk of side effects. It’s best to follow a schedule created by a medical professional.
What happens when you stop taking NAD+?
When you stop NAD+ therapy, your body gradually returns to its natural NAD+ levels. Any benefits you experienced may fade over time, but there are no known withdrawal effects.
What are the disadvantages of NAD+?
Possible downsides include mild side effects like nausea, headaches, or flushing, as well as rare issues such as liver enzyme changes. Some concerns remain about its effects in certain health conditions.
Can I take NAD+ with magnesium?
Yes, in most cases NAD+ and magnesium can be taken together, but you should confirm with a healthcare provider to ensure they’re safe for your specific situation.
Can NAD+ reverse aging?
NAD+ can support healthy aging by helping with energy production and cell repair, but it doesn’t reverse aging. Research shows it may slow some age-related processes, not stop them entirely.
